Two mesa pilots in a CRJ fell asleep, overshot one of the Hawaiian islands, headed out to sea and almost flamed out before they made it back to land. CA had OSA for sure, I believe that incident was the catalyst although the post-colgan fatigue studies probably played a role.

Also any of a number of fatigue-involved accidents might have been affected in the past. It's a reasonable suspicion, and can't be disproved.