I'm C-130 driver for the Reserves and chose to go the regional route. I would highly recommend it to check the 121 box, add a type rating, and build hours. Having the flexibility to do both jobs is awesome. You definitely do not want to commute to both. I'm home based for the airline and commute for a 1 hour flight to the Reserves. I drop MIL leave in moderation and I've never had a problem with pay or the airline. Send me a PM if you have questions, I'd be happy to help.
Herc