I just met a captain that's been doing the STL-DEN commute for 8 years. Two guys in my class are doing it as well. I've wanted to live out there for a while and I might consider it once I can afford it.
You have a ton of flights to choose from. Frontier and United mainline seem to be the best bets. Sounds like the ERJs get weight restricted out of there during the summer. As crazy as it sounds, if the loads look really bad, it's a 12 hour drive down 70 if you do the speed limit, and stop every two hours.