A few recommendations:
1. Go get a biannual flight review with a local CFI. Get current on the profession. So many changes.
2. Get an instrument proficiency check with a local CFI. Before doing this, do a few instrument refresher.
3. If you don't have an ATP, get one. The BFR and the Instrument work is a good lead in into doing this. Make sure do it a multi engine AC.
After the 3 steps above are done get on with a regional airline. That will get your proficiency up to date and get you squared away with 121 from a knowledge perspective and application perspective. It will check the box for 121 experience for the majors.
Time to majors from doing the above is likely 1 to 1.5 years.