Depends on your lifestyle and flexibility, and what you want to do with the travel bennies.
You can go anywhere domestic using JS privileges, as long as you're a 121 pilot, on pretty much any airline.
If you want to go international, with traveling companions, then some regionals with multiple major partners might make more sense. SKW CRJ pilots get both DAL and UAL, which can be nice.
But for most folks it won't really matter