Couple more thoughts -

Are you going to be a Quality of Life or Max Paycheck kind of guy? Because of my Check of the Month status, I am a QOL guy who generally works as little as possible. I drop trips regularly and sometimes take Leaves of Absence during the slow seasons. I'm home more with the family as a result, and my wife loves my job these days. When my oldest kids have flown the coop in a few years, I might pick up the flying pace... or not. Without that extra monthly income and the relatively low starting pay, you might not have much choice but to work the max out of the gate (which would be that much worse for QOL if you end up commuting).

Currency requirements - For SWA their page says "Experience should include actively flying two of the last five years". If you've just gotten back in the saddle, applying immediately after getting 100 'recent' hours may not cut the mustard. Not sure where the other majors draw the line these days, but a solid year or two of flying may be needed. With decent flying for the next year or so, I don't think it would cause any issues on your app if you got tagged for a 180/365 no-flying tour close to retirement (God forbid).