If you have basic stick and rudder skills, can crack a book, and are able to admit when you don't know something then making the transition from one kind of flying to another is not rocket surgery. Whether that be Ameriflight to Omni or CFI to RJ or 207 to 727.
The flow had worked out well for tge guys I know who've done it. Most get to keep living where they are and are now poised to increase their income tremendously.