I have two 121 failures that were over 10 years ago now. I’ve got called by two of the big six with the events on my application. Only one asked about them and moved on with the interview. The other didn’t even care to ask about them.
My good friend also had two 121 busts. He forgot to put the O2 mask on while the CA was out of the flight deck and the fed up front busted him. He also failed his upgrade ride and had to go back to being an FO for a while. He’s a Delta now. So I think you have a chance. Perhaps talk with a consultant or two on how best to present the failures.
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