Where do you want to live? Go to the one that allows you to drive to work.
From there if it requires commuting (you mentioned one leg), go to the one with the fastest seniority movement at the easiest commute.
After that, AA has always lagged the other airlines in pay and work rules.
More than five years out, what’s going on today bears zero resemblance to what will be will be going on when it’s time for you to retire.