So you are looking to bypass the regionals and go straight to a major?

I'm in a similar boat. I've got 1,050 hours logged on the right side of an ERJ-145, but my last landing was Dec 15th, 2008. I've been flying since then, but only in GA. I own a Piper Cherokee and fly around VFR about 10-12 hours a month. Not "competitive" flying, but it's something regular in the book.

I have no doubt I could get back on with a regional lickity split if I wanted to. But, to a major directly? Nope.