I've commuted from Phoenix to both LA and SFO. They're both pretty easy if you leave yourself with 3-4 backups. In LA I would often have to go to my first backup, sometimes my second. In SFO I don't have to use my backups too often, but I have flown into San Jose and Oakland when the clouds are over SFO. My seniority goes further in SFO on the 777, that's why I commute there. You do have to have a good mindset though, commuting isn't for everyone.