if you were a military pilot with 500-1000 hours turbine PIC time, you should stay at PSA; within 300-400 hours of currency you should be competetive for a interview invite.
Anyone else: moving from one regional to another is only excusable if it is to be home-based. You are giving up seniority, schedule advantage, and going into jeopardy events. Go wherever you can get 1000 hours multi-turbine PIC the fastest, then get hired at a major/legacy.