There is a work-around on PIC.
Get some turbine PIC in anything (1000 hours preferred, 1500 if possible). TPIC in a 'van, etc will not get you a top-tier job.
But combine that with some 121 glass jet SIC and it might do the trick. So if you're a junior regional FO and hitting the streets anyway, I'd look to places like Empire, etc.
135/91 TPIC + regional SIC is better than no PIC, and allows to at least apply to any airline which has a PIC requirement (that may be coming back for a few years).