My bag never changes, doesn't matter the length of the trip. I pack for 8 days.
Clothes never change out either. Work clothes and home clothes.
Laundry is a given, most places are card, some are coin. But front desk always has soap and coins.
I personally do laundry the night before I go home as well and the bag goes into the closet untouched when I am home. Comes right back out when I leave. Work is work. Home is home.
Stores are also generally found everywhere if you need something.