Great thread!
Having worked at JetBlue and now NJA I get asked all the time by fellow pilots in my reserve squadron which route they should take. Of course I can't answer for them but I can certainly give them a detailed list of the pros/cons of each, at least in my view.
For me, commuting is the deciding factor with regard to the airlines. If you live in a domicile or are willing to move to one, then go for it. Commuting? NJA all the way! I can tell you the ability to choose from 100 crew bases and be able to change with 30 days notice is incredible.
I live about an hour from a SWA domicile (BWI) and if offered a job there I would certainly think long and hard about it. If I had to commute, I wouldn't even consider it.
Best of luck to everyone in this chaotic industry!