You have to choose the wife carefully. There are many women who say they don't mind you being gone and after a few years make your life miserable. At the junior end of a seniority list you will be gone MOST of the month. Don't drink the kool-aid most 121 guys give you about being home. That takes seniority.
That being said, my wife understands the schedule and is independent enough she enjoys it almost as much as I enjoy my profession. It's not the 7 days away that will annoy her, or you. It's the being away. If she is alright with that, keep flying! You love it or wouldn't be doing it. If she ain't alright with it and you love her more, time to pick a new profession.
Fractionals treat you better than ANY 121 carrier. Personal experience speaking here. On the job you are happier. Off the job, I hope you get that one figured out. Good luck and best wishes!