Advise
If you are young and have time to burn I would stay until I had 1000K of Jet PIC then go to a regional. I don't think most airlines prefer flexjet types. They seem to like 121 better. The bottom line however is your contacts. You could have 1000 hours of shuttle command time and it would be useless in this market unless you had some strong contacts. The regionals offer more exposure to commuting pilots, that could help. Leaving with less than the 1000 hours of Jet pic would be a big risk. I have friends with 350 to 500 hours of 757 PIC and they can't even apply to most companies. They might as well have glider time because it is just as worthless.
SkyHigh