I've had a few...one during climb out in turbulence on profile airspeed (tells me to screw 200 KIAS when we're getting in the moderate bumps -- airspeed is our friend), and twice during flare in the -200 (both greasers, of course). If one were completely fatigued, I can see some initial confusion if you're not a particularly strong Pilot to begin with, so I think 250 has a point...BUT I don't care what they train me for, my butt will fly the plane out of anything...it's a shoot-from-the-hip, save your own ass, instinctual thing.