Personally I hope the FAA makes a change to this reg,
and make it as clear as the new clean wing thing, where even polished frost is considered a contaminated wing and subjects you to a violation.
I know of a company who draws the line, according to their POI " on call is on duty" and if they can't complete the flight in 14 hours from the time they start " on call " another pilot flies the trip.
My employer is very safety conscious and if someone were to refuse a trip due to fatigue, I doubt they would even think twice about it ...but doing it too much and you mind find yourself looking for another job.
unfortunately in my experience this is either a gray area or an ignored and exploited area, then again I have refused to fly airplanes on more than one occasion, and for more than one employer and have never been fired for that yet.