Generally, it would meet the typical MINIMUM published requirements at many major airlines. In the last hiring wave, I recall at least one airline specify a requirement for time in a heavier airplane I think > 30,000# or something like that.

But unless you are really well connected, majors will probably not consider you competitive...cheyenne flying is really more GA than anything else.

If you combined that with some regional SIC, it might work...the cheyenne TPIC to meet the technical requirement, the RJ time to show that you can do airline operations.