The degree thing won't be an issue if you have life experience to off set it. The biggest thing is currency and recency of experience.

Got do a BFR. Get instrument current. Log 100 hrs or so in a quick amount of time (multi is certainly better). Get 100 ME under your belt, and get back to proficiency both in the airplane and with regards to knowledge.

If you really want to fly (and can "afford" to do so in all the various aspects of doing so), then you shouldn't have too much trouble once you get proficient again. 800/100 is pretty competitive for some of the smaller/starter regionals (Colgan for example).