Unless you absolutely want to be an airline pilot right now, at any cost, I'd recommend staying put. The regionals will be hurting for qualified pilots very soon and you should be able to snag a job at a regional, if not a LCC, fairly easily. Can you get to a major from your current position? Sure, network and build that turbine PIC.

The good side of regional airlines: with some seniority you can get a good schedule with lots (relatively speaking) of planned days off. The bad: pay.