It will help a little, but probably only at the airline you work for. If that's your motivation for taking the job, make sure you fit the pilot profile at that airline (ie eagle = very clean record all around, no checkride failures).

I wouldn't pass up a better paying job to throw bags...tens thousands of people have been hired at regionals without ever working the ramp. But if that's the payscale range you'll be in regardless, might as well. Plus you get travel bennies, for whatever that's worth to a non-pilot.

I have also heard of regional captains working the ramp at SWA, FDX, etc on their days off in order to take advantage of internal hiring preferences.