Vaccine Development Summary
09-14-2020, 07:08 PM
#212
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Originally Posted by Humbleavi8t0r
An artificial antibody injected into your system probably wears out after weeks or months at the most, since your immune system is not making more of them. If you want more, you'd have to frequent injections. Could perhaps be useful as an interim vaccine, but they obviously have to do a lot of trials first.
09-14-2020, 09:28 PM
#213
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China may have multiple vaccines available to the public in Nov. No shortcuts (as far as we know) for the public certification.
https://www.reuters.com/article/us-h...-idUSKBN2660DW
https://www.reuters.com/article/us-h...-idUSKBN2660DW
09-15-2020, 04:38 AM
#214
Gets Weekends Off
Joined APC: Nov 2019
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In a big blow to the expectations regarding the covid-19 vaccine, the Serum Institute of India has said adequate coronavirus vaccine will not be available for everybody in the world to be immunised until the end of 2024.
The chief executive of the world’s largest manufacturer of vaccines, Adar Poonawalla, has said dampened the hopes of a COVID-19 vaccine by year-end in an interview with the Financial Times. He said that pharma firms were not ramping up production capacity swiftly to be able to innoculate the world population in less duration.
The chief executive of the world’s largest manufacturer of vaccines, Adar Poonawalla, has said dampened the hopes of a COVID-19 vaccine by year-end in an interview with the Financial Times. He said that pharma firms were not ramping up production capacity swiftly to be able to innoculate the world population in less duration.
https://www.wionews.com/india-news/c...e-chief-327456
09-15-2020, 06:51 AM
#215
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Originally Posted by senecacaptain
apparently having a vaccine, and actually getting vaccinated, are two different things.
https://www.wionews.com/india-news/c...e-chief-327456
https://www.wionews.com/india-news/c...e-chief-327456
Certain countries have taken pre-emptive measures to mfg adequate quantities of several candidate vaccines in advance, including the US. Assuming one of those gets certified, the only delay is in the physical distribution (and they're preparing for that too).
Also it seems that if the developed world ramped up production, they could get enough distributed globally within a year or two. Many governments (and the UN) will do that out of benevolence, if not economic-self interest. While there are billions of destitute people in the world, somehow we manage get 99% of them an current-model iPhone...
09-17-2020, 08:40 PM
#216
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Pfizer is pressing hard to be one of the first to market...
https://www.reuters.com/article/us-h...-idUSKBN26835O
https://www.reuters.com/article/us-h...-idUSKBN26835O
09-17-2020, 09:09 PM
#217
Perennial Reserve
Joined APC: Jan 2018
Posts: 11,533
Originally Posted by rickair7777
Pfizer is pressing hard to be one of the first to market...
https://www.reuters.com/article/us-h...-idUSKBN26835O
https://www.reuters.com/article/us-h...-idUSKBN26835O
The protocol calls for a first assessment of the vaccine’s performance by the monitoring board after 32 participants in the trial become infected with the novel coronavirus. Pfizer’s vaccine would need to be at least 76.9% effective to show it works based on 32 infections, according to its protocol. That would mean that no more than six of those coronavirus cases would have occurred among people who received the vaccine, the documents showed.
It took five years to demonstrate it with dengvaxia.
https://www.virology.ws/2017/12/07/a...virus-vaccine/
If the FDA buys off on that as a statistically adequate sampling it will be no different than the FAA closing their eyes and approving MCAS on Boeing’s say so.
09-18-2020, 07:21 AM
#218
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Originally Posted by Excargodog
Your chances of detecting even a fairly serious incidence of antibody dependent enhancement on an n of 6 is so close to zero it might as well be.
It took five years to demonstrate it with dengvaxia.
https://www.virology.ws/2017/12/07/a...virus-vaccine/
If the FDA buys off on that as a statistically adequate sampling it will be no different than the FAA closing their eyes and approving MCAS on Boeing’s say so.
It took five years to demonstrate it with dengvaxia.
https://www.virology.ws/2017/12/07/a...virus-vaccine/
If the FDA buys off on that as a statistically adequate sampling it will be no different than the FAA closing their eyes and approving MCAS on Boeing’s say so.
However... ADE (caused by the vaccine) would not likely show up in normal phase-3 trials anyway, that's a phase-4 kind of thing. There's no requirement that mfgs and regulators wait for years after phase-3 to see if anything pops up before certification, if that standard is good enough for routine pharmas, not sure why covid should be any different.
Also ADE is not particularly likely in the coronavirus family (according to experts, not me), despite being an RNA virus (like covid) Dengue has quite a different infection mechanism, so kind of apples to oranges.
09-18-2020, 08:14 AM
#219
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Posts: 11,533
Originally Posted by rickair7777
.
Also ADE is not particularly likely in the coronavirus family (according to experts, not me), despite being an RNA virus (like covid) Dengue has quite a different infection mechanism, so kind of apples to oranges.
Also ADE is not particularly likely in the coronavirus family (according to experts, not me), despite being an RNA virus (like covid) Dengue has quite a different infection mechanism, so kind of apples to oranges.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311339/
https://advances.massgeneral.org/research-and-innovation/article.aspx?id=1186
https://news.berkeley.edu/2020/09/09...es-to-t-cells/
https://www.globaltimes.cn/content/1200686.shtml
in fact, some researchers are now theorizing that the so-called cytokines storm seen in many of the most severe cases IS ADE caused by antibodies against the four human coronavirus that routinely circulate and just cause colds.
and ADE certainly is believed to play a prominent part in the pathology of SARS:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377703/
And was seen in animal testing in a now abandoned MERS vaccine:
https://journals.plos.org/plospathog...l.ppat.1006565
and that’s been long known in feline coronavirus infections:
https://jvi.asm.org/content/jvi/64/3/1407.full.pdf
So you may be listening to the wrong experts.
09-22-2020, 10:46 AM
#220
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Position: Engines Turn Or People Swim
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Article on vaccine allocation considerations, no real surprises...
https://www.npr.org/sections/health-...d-get-it-first
https://www.npr.org/sections/health-...d-get-it-first
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