Anson Harris

Everytime you write "Hydroxy-C" I think of gym bros and Hydroxycut.

I don't remember who on this site originally cited this, but EVMS was on to the benefits of anti-inflammatory treatment months ago. I don't think they were specifically using dexamethasone, but anti-inflammatory treatment was a huge part of their protocol (and avoiding intubation).

It has to be said that WHO/CDC specifically recommended against anti-inflammatory treatment of COVID-19, costing who knows how many lives. We all make mistakes, but the number and magnitude of the errors made by public health institutions have been scandalous and unbelievably costly.

rickair7777

On the vaccine front, USG intends to focus on the seven which look to have the most promise, shooting for Jan availability. Vaccine(s) will be free according to the gov.

https://www.reuters.com/article/us-h...-idUSKBN23N2CV

ShyGuy

Who wants a free vaccine shot from the government? Free autism for everyone! And if you don't get autism, they'll always be able to track you with the microchip they insert in the vaccine.

furloughfuntime

the government doesn't need to put a tracking device in vaccines because people already willingly carry tracking and listening devices on them at all times

firefighterplt

I think it was methylprednisolone in the EVMS protocol? Not sure

Anson Harris

I believe you're correct. But in any case they were early advocates for treating COVID with anti-inflammatories and anti-coagulants (and trying to avoiding intubation and its associated baggage). Their protocol also discusses how much more practical this is than a designer drug for a worldwide disease, which is the same point made about dexamethasone.

I wonder if more COVID patients have been killed by ventilators than have been saved at this point. Pure speculation on my part, but it wouldn't surprise me.

ZapBrannigan

Not a vaccine, but a synthetic antibody.

Vaccines can't cure the sick, and take months to protect the healthy. Antibodies do both within days. Amazing!

https://www.forbes.com/sites/johncum...-treat-humans/


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rickair7777

All correct, especially the treatment/cure part.

However...

It will work in place of a vaccine but only for a limited time period. Antibodies injected into your system will wear out or get flushed out eventually. Timeline? I'd be surprised if you keep a high enough concentration for more than a few weeks or months. Maybe less.

A vaccine "trains" your immune system to make it's own antibodies. Your system remembers how to do that for a period of time typically measured in years, in some cases a lifetime. An antibody used as a preventative in place of a vaccine would need to be re-administered frequently, maybe weekly. Probably impractical.

Still going to need a vaccine but a good antibody treatment could really reduce severity/death in the high-risk cases, maybe essentially eliminate fatalities. It would be a lot easier to make enough of it if initially it's only used to treat more severe cases.

ZapBrannigan

Yes excellent point. I should have said that it would be a bridge to a vaccine. Cure the severely ill and protect front line medical professionals.


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Anson Harris

It has been fascinating to follow the development of the EVMS protocol over the last three months. The latest 6/17 update now discusses the Dexamethasone study results They think this validates their approach, but they still prefer Methylprednisolone as a more effective treatment.

It's a great read for understanding the epidemic, and there's almost no aspect of the disease and treatment that it doesn't touch on (hydroxycloroquine, remdesivir, plasma exchange, ventilators). The general media coverage is unhelpful because it's typically single-subject and abhors nuance.

It appears that they are starting to get a good handle on covid, so it would not be surprising if the death and ICU rate continues to decline even if cases go up.

One thing that puzzles me is why there hasn't been any focus on preventive measures (other than masks) and at-home covid treatment (as far as I know). I've been making sure to take my vitamins, but there doesn't seem to be any effort to make sure the population isn't deficient. I don't have any experience with covid, but are they doing anything for people who are suspected/known positive at home? Seems like there could be a lot of creative solutions to avoid progressing to needing hospitalization.