Vaccine Development Summary
12-15-2021, 09:15 PM
#1081
:-)
Joined APC: Feb 2007
Posts: 7,339
Originally Posted by rickair7777
Pfizer two-dose regimen less effective against omicron, but still provides 70% protection against hospitalization (vice 93% against delta). This in no way addresses the statistical severity of omicron, which still appears lower than previous big variants.
https://www.reuters.com/business/hea...dy-2021-12-14/
Also more details on the WSJ.
https://www.reuters.com/business/hea...dy-2021-12-14/
Also more details on the WSJ.
The evolution of the virus is actually keeping people out of the hospital.
12-15-2021, 09:21 PM
#1082
Perennial Reserve
Joined APC: Jan 2018
Posts: 11,503
A panel of advisers for the Centers for Disease Control and Prevention (CDC) will meet on Thursday to consider whether to impose restrictions on the Johnson & Johnson COVID-19 vaccine due to new data on rare blood clot issues, The Washington Post reported.
The Post, citing clinicians familiar with the meeting’s agenda, reported that the Advisory Committee on Immunization Practices will receive information indicating that blood clot rates have risen, particularly in younger women, though the issue remains extremely rare.
One federal official told the newspaper that nine people have died due to blood clotting complications related to the vaccine.
Previous reports confirmed that at least four people had diedfrom the complications associated with the company's vaccine. According to the Food and Drug Administration, women between the age of 30 and 49 years old have reported the highest rate of blood clotting issues, the Post noted.“We are committed to understanding and communicating all known risks, including rare events of [the blood clot condition], and strongly support raising awareness of the signs and symptoms of this rare event,” Johnson & Johnson spokesperson, Jake Sargent, told The Post in an email.
One clinician who spoke with the newspaper said that advisors could either recommend the vaccine for use for certain populations, stop using it altogether or keep its current recommendation unchanged — suggestions that that are subject to final sign-off by CDC Director Rochelle Walensky.
The Post, citing clinicians familiar with the meeting’s agenda, reported that the Advisory Committee on Immunization Practices will receive information indicating that blood clot rates have risen, particularly in younger women, though the issue remains extremely rare.
One federal official told the newspaper that nine people have died due to blood clotting complications related to the vaccine.
Previous reports confirmed that at least four people had diedfrom the complications associated with the company's vaccine. According to the Food and Drug Administration, women between the age of 30 and 49 years old have reported the highest rate of blood clotting issues, the Post noted.“We are committed to understanding and communicating all known risks, including rare events of [the blood clot condition], and strongly support raising awareness of the signs and symptoms of this rare event,” Johnson & Johnson spokesperson, Jake Sargent, told The Post in an email.
One clinician who spoke with the newspaper said that advisors could either recommend the vaccine for use for certain populations, stop using it altogether or keep its current recommendation unchanged — suggestions that that are subject to final sign-off by CDC Director Rochelle Walensky.
https://thehill.com/policy/healthcar...od-clot-issues
12-16-2021, 06:26 AM
#1083
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,293
Originally Posted by Mesabah
The new studies coming out show Omicron doesn't become a vascular disease, and stays on the outside of the lung tissue. The vaccine plays no role in the infection process, mucosal immunity from natural infection probably is helpful, and conserved from previous variants. https://www.med.hku.hk/en/news/press...ov-2-infection
The evolution of the virus is actually keeping people out of the hospital.
The evolution of the virus is actually keeping people out of the hospital.
12-16-2021, 06:51 AM
#1084
:-)
Joined APC: Feb 2007
Posts: 7,339
Originally Posted by rickair7777
I doubt the vaccines plays "no role", since they've already observed some vaccine efficacy, at least with a recent booster. May also depend on which vaccine you're talking about, since there are variety world-wide.
12-16-2021, 06:55 AM
#1085
Perennial Reserve
Joined APC: Jan 2018
Posts: 11,503
Originally Posted by Mesabah
In the very short term, the vaccines will induce some mucosal immunity. https://www.medrxiv.org/content/10.1....01.21261297v1
12-16-2021, 07:47 AM
#1086
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,293
Originally Posted by Mesabah
In the very short term, the vaccines will induce some mucosal immunity. https://www.medrxiv.org/content/10.1....01.21261297v1
12-16-2021, 04:20 PM
#1087
Banned
Joined APC: Sep 2015
Position: 3+ hour sit in the ATL
Posts: 1,982
Originally Posted by rickair7777
I doubt the vaccines plays "no role", since they've already observed some vaccine efficacy, at least with a recent booster. May also depend on which vaccine you're talking about, since there are variety world-wide.
Rapid Progression of Angioimmunoblasitc T-Cell Lymphoma Following BNT162b2 mRNA booster
Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
https://www.ncbi.nlm.nih.gov/labs/pm...es/PMC8656165/
Published in Nov 2021
Yeah, the mRNA [vaccines] don't accelerate cancer growth either in otherwise normal people. Until they do.
12-16-2021, 08:52 PM
#1088
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,293
Originally Posted by Drum
Uh-oh
Rapid Progression of Angioimmunoblasitc T-Cell Lymphoma Following BNT162b2 mRNA booster
Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
https://www.ncbi.nlm.nih.gov/labs/pm...es/PMC8656165/
Published in Nov 2021
Yeah, the mRNA [vaccines] don't accelerate cancer growth either in otherwise normal people. Until they do.
Rapid Progression of Angioimmunoblasitc T-Cell Lymphoma Following BNT162b2 mRNA booster
Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
https://www.ncbi.nlm.nih.gov/labs/pm...es/PMC8656165/
Published in Nov 2021
Yeah, the mRNA [vaccines] don't accelerate cancer growth either in otherwise normal people. Until they do.
There are a variety of medical conditions which contraindicate vaccination. So perhaps docs should advise AITL patients not to get mRNA vaccines?
12-20-2021, 06:20 AM
#1089
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,293
Summary of vaccine efficacy against omicron...
AZ has zero efficacy, similar for J&J and several foriegn vaccines.
Moderna & pfizer fare better, still 70% against severe disease. Yes, odds of severe omicron appear low but within that you can still observe if vaccines make it lower... that's actually important because omicron appears so contagious it still might overwhelm critical care capacity if everybody got it all at one.
https://www.newsnationnow.com/mornin...icron-variant/
WSJ also reporting that Moderna with booster looks very good against omicron in lab analyses.
AZ has zero efficacy, similar for J&J and several foriegn vaccines.
Moderna & pfizer fare better, still 70% against severe disease. Yes, odds of severe omicron appear low but within that you can still observe if vaccines make it lower... that's actually important because omicron appears so contagious it still might overwhelm critical care capacity if everybody got it all at one.
https://www.newsnationnow.com/mornin...icron-variant/
WSJ also reporting that Moderna with booster looks very good against omicron in lab analyses.
12-20-2021, 06:49 AM
#1090
:-)
Joined APC: Feb 2007
Posts: 7,339
Originally Posted by rickair7777
Summary of vaccine efficacy against omicron...
AZ has zero efficacy, similar for J&J and several foriegn vaccines.
Moderna & pfizer fare better, still 70% against severe disease. Yes, odds of severe omicron appear low but within that you can still observe if vaccines make it lower... that's actually important because omicron appears so contagious it still might overwhelm critical care capacity if everybody got it all at one.
https://www.newsnationnow.com/mornin...icron-variant/
WSJ also reporting that Moderna with booster looks very good against omicron in lab analyses.
AZ has zero efficacy, similar for J&J and several foriegn vaccines.
Moderna & pfizer fare better, still 70% against severe disease. Yes, odds of severe omicron appear low but within that you can still observe if vaccines make it lower... that's actually important because omicron appears so contagious it still might overwhelm critical care capacity if everybody got it all at one.
https://www.newsnationnow.com/mornin...icron-variant/
WSJ also reporting that Moderna with booster looks very good against omicron in lab analyses.
The AZ and J&J viral vector adjuvant, targets cellular responses to the spike, which are worthless with coronaviruses. I posted about all of this over a year ago.
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