As for schedule changes, you get all kinds. You may deadhead around the world to operate a single leg (my personal best in 6 months on line - I went 20,000 miles to operate a 1.5 hour flight) or you may leave home, land at, say, ORD thinking you're going to catch a connection to your trip and instead be sent home. Roll with the punches.
I don't care what happens once I leave, so the only frustrating aspect has been when it happens while i'm home and I get put on Home Reserve. Babysitters/day care centers aren't as rapid to adjust to the changes as I am.